Targeting influenza A virus by splicing inhibitor herboxidiene reveals the importance of subtype-specific signatures around splice sites

Targeting influenza A virus by splicing inhibitor herboxidiene reveals the importance of subtype-specific signatures around splice sites

Abstract Background The association between M segment splicing and pathogenicity remains ambiguous in human influenza A viruses. In this study, we aimed to investigate M splicing in various human influenza A viruses and characterize its physiological roles by applying the splicing inhibitor, herboxi...

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Bibliographic Details
Main Authors: Yi-Ju Han, Kuo-Ming Lee, Guan-Hong Wu, Yu-Nong Gong, Avijit Dutta, Shin-Ru Shih
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Journal of Biomedical Science
Subjects:
Influenza A virus
Pathogenicity
Splicing
Herboxidiene
Subtype-specific signature
M2 protein
Online Access:https://doi.org/10.1186/s12929-023-00897-4

Internet

https://doi.org/10.1186/s12929-023-00897-4

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