In Vitro–In Silico Modeling of Caffeine and Diclofenac Permeation in Static and Fluidic Systems with a 16HBE Lung Cell Barrier

In Vitro–In Silico Modeling of Caffeine and Diclofenac Permeation in Static and Fluidic Systems with a 16HBE Lung Cell Barrier

Static in vitro permeation experiments are commonly used to gain insights into the permeation properties of drug substances but exhibit limitations due to missing physiologic cell stimuli. Thus, fluidic systems integrating stimuli, such as physicochemical fluxes, have been developed. However, as flu...

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Bibliographic Details
Main Authors: Lukas Kovar, Lena Wien, Dominik Selzer, Yvonne Kohl, Robert Bals, Thorsten Lehr
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Pharmaceuticals
Subjects:
in vitro–in silico modeling
16HBE
caffeine
diclofenac
fluidic system
static system
Online Access:https://www.mdpi.com/1424-8247/15/2/250

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https://www.mdpi.com/1424-8247/15/2/250

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