The IL‐21‐TET2‐AIM2‐c‐MAF pathway drives the T follicular helper cell response in lupus‐like disease

The IL‐21‐TET2‐AIM2‐c‐MAF pathway drives the T follicular helper cell response in lupus‐like disease

Abstract Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that involves T follicular helper (TFH) cell‐mediated humoral immune responses. Absent in melanoma 2 (human AIM2 and murine Aim2) is a well‐known component of the inflammasome in the innate immune system. Surprisingly, we ob...

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Bibliographic Details
Main Authors: Haijing Wu, Yaxiong Deng, Di Long, Ming Yang, Qianwen Li, Yu Feng, Yongjian Chen, Hong Qiu, Xin Huang, Zhenghao He, Longyuan Hu, Heng Yin, Guangdi Li, Yunkai Guo, Wenhan Du, Ming Zhao, Liwei Lu, Qianjin Lu
Format: Article
Language:English
Published: Wiley 2022-03-01
Series:Clinical and Translational Medicine
Subjects:
AIM2
systemic lupus erythematosus (SLE)
T follicular helper cells (TFH)
Online Access:https://doi.org/10.1002/ctm2.781

Internet

https://doi.org/10.1002/ctm2.781

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