CRISPR/Cas9 disruption of EpCAM Exon 2 results in cell-surface expression of a truncated protein targeted by an EpCAM specific T cell engager

CRISPR/Cas9 disruption of EpCAM Exon 2 results in cell-surface expression of a truncated protein targeted by an EpCAM specific T cell engager

CRISPR/Cas9 gene-editing technology allows researchers to study protein function by specifically introducing double-stranded breaks in the gene of interest then analyze its subsequent loss in sensitive biological assays. To help characterize one of a series of highly potent, conditionally active, T...

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Bibliographic Details
Main Authors: Andisheh Bagheri, Patricia A. Culp, Robert B. DuBridge, Tseng-hui Timothy Chen
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Biochemistry and Biophysics Reports
Subjects:
CRISPR
Bispecific
COBRA
EpCAM
Exon-skipping
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580822000061

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http://www.sciencedirect.com/science/article/pii/S2405580822000061

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