Design, Synthesis and Biological Evaluation of [1,2,4]Triazolo[1,5-<i>a</i>]pyrimidine Indole Derivatives against Gastric Cancer Cells MGC-803 via the Suppression of ERK Signaling Pathway

Design, Synthesis and Biological Evaluation of [1,2,4]Triazolo[1,5-<i>a</i>]pyrimidine Indole Derivatives against Gastric Cancer Cells MGC-803 via the Suppression of ERK Signaling Pathway

[1,2,4]Triazolo[1,5-<i>a</i>]pyrimidine and indole skeletons are widely used to design anticancer agents. Therefore, in this work, a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine indole derivatives were designed and synthesized by the molecular hybridization strategy. The...

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Bibliographic Details
Main Authors: Guang-Xi Yu, Ying Hu, Wei-Xin Zhang, Xin-Yi Tian, Sai-Yang Zhang, Yan Zhang, Shuo Yuan, Jian Song
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Molecules
Subjects:
[1,2,4]triazolo[1,5-<i>a</i>]pyrimidine
indole
antiproliferative activities
ERK signaling pathway
Online Access:https://www.mdpi.com/1420-3049/27/15/4996

Internet

https://www.mdpi.com/1420-3049/27/15/4996

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