Replisome Dynamics and Their Functional Relevance upon DNA Damage through the PCNA Interactome

Summary: Eukaryotic cells use copious measures to ensure accurate duplication of the genome. Various genotoxic agents pose threats to the ongoing replication fork that, if not efficiently dealt with, can result in replication fork collapse. It is unknown how replication fork is precisely controlled...

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Bibliographic Details
Main Authors: Mrinal Srivastava, Zhen Chen, Huimin Zhang, Mengfan Tang, Chao Wang, Sung Yun Jung, Junjie Chen
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718318904