Expression of Dectin-1 and Enhanced Activation of NALP3 Inflammasome Are Associated with Resistance to Paracoccidioidomycosis

Expression of Dectin-1 and Enhanced Activation of NALP3 Inflammasome Are Associated with Resistance to Paracoccidioidomycosis

Dectin-1 is a pattern recognition receptor (PRR) that recognizes β-glucans and plays a major role in the immunity against fungal pathogens. Paracoccidioides brasiliensis, the causative agent of paracoccidioidomycosis, has a sugar-rich cell wall mainly composed of mannans and glucans. To investigate...

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Bibliographic Details
Main Authors: Vera Lucia Garcia Calich, Claudia eFeriotti, Silvia B. Bazan, Flavio Vieira Loures, Eliseu Frank Araujo, Tania A. Costa
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-09-01
Series:Frontiers in Microbiology
Subjects:
innate immunity
Paracoccidioides brasiliensis
NLRP3 inflammasome
M1/M2 macrophages
Dectin-1 Receptor
Resistance to Paracoccidioidomycosis
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00913/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00913/full

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