Mechanotransduction pathways in articular chondrocytes and the emerging role of estrogen receptor-α

Abstract In the synovial joint, mechanical force creates an important signal that influences chondrocyte behavior. The conversion of mechanical signals into biochemical cues relies on different elements in mechanotransduction pathways and culminates in changes in chondrocyte phenotype and extracellu...

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Bibliographic Details
Main Authors: Ning Wang, Yangfan Lu, Benjamin B. Rothrauff, Aojie Zheng, Alexander Lamb, Youzhen Yan, Katelyn E. Lipa, Guanghua Lei, Hang Lin
Format: Article
Language:English
Published: Nature Publishing Group 2023-03-01
Series:Bone Research
Online Access:https://doi.org/10.1038/s41413-023-00248-x