Synthetic enhancers including TFREs improve transgene expression in CHO cells

Synthetic enhancers including TFREs improve transgene expression in CHO cells

The human cytomegalovirus major immediate early gene (CMV) promoter is currently the most preferred promoter for recombinant therapeutic proteins (RTPs) production in CHO cells. To enhance the production of RTPs, five synthetic enhancers including multiple transcription factor regulatory elements (T...

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Bibliographic Details
Main Authors: Hui-Ning Liu, Xiao-Yin Wang, Ying Zou, Wen-Bao Wu, Yan Lin, Bo-Yu Ji, Tian-Yun Wang
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Heliyon
Subjects:
Recombinant proteins
CHO cell expression system
CMV promoter
Synthetic promoter
Enhancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024029323

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http://www.sciencedirect.com/science/article/pii/S2405844024029323

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