The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding

The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding

Kinesin-5 motors organize mitotic spindles by sliding apart microtubules. They are homotetramers with dimeric motor and tail domains at both ends of a bipolar minifilament. Here, we describe a regulatory mechanism involving direct binding between tail and motor domains and its fundamental role in mi...

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Bibliographic Details
Main Authors: Tatyana Bodrug, Elizabeth M Wilson-Kubalek, Stanley Nithianantham, Alex F Thompson, April Alfieri, Ignas Gaska, Jennifer Major, Garrett Debs, Sayaka Inagaki, Pedro Gutierrez, Larisa Gheber, Richard J McKenney, Charles Vaughn Sindelar, Ronald Milligan, Jason Stumpff, Steven S Rosenfeld, Scott T Forth, Jawdat Al-Bassam
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-01-01
Series:eLife
Subjects:
kinesin-5
motor protein
Microtubule
sliding
mitosis
mitotic spindle
Online Access:https://elifesciences.org/articles/51131

Internet

https://elifesciences.org/articles/51131

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