Selective estrogen receptor modulators decrease invasiveness in pituitary adenoma cell lines AtT‐20 and TtT/GF by affecting expression of MMP‐14 and ADAM12

Selective estrogen receptor modulators decrease invasiveness in pituitary adenoma cell lines AtT‐20 and TtT/GF by affecting expression of MMP‐14 and ADAM12

Selective estrogen receptor modulators (SERMs) significantly affect survival and invasiveness of rodent pituitary adenoma (PA) cells. The impact of three clinically relevant SERMs (bazedoxifene, clomiphene, raloxifene) on invasiveness and on gene and protein expression of invasion‐related proteases...

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Bibliographic Details
Main Authors: Zhuo Zhang, Jörg W. Bartsch, Julia Benzel, Ting Lei, Christopher Nimsky, Benjamin Voellger
Format: Article
Language:English
Published: Wiley 2020-11-01
Series:FEBS Open Bio
Subjects:
ADAM proteases
anti‐estrogens
invasiveness
matrix metalloproteinases
pituitary adenoma
Online Access:https://doi.org/10.1002/2211-5463.12999

Internet

https://doi.org/10.1002/2211-5463.12999

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