In vivo multi-parametric manganese-enhanced MRI for detecting amyloid plaques in rodent models of Alzheimer’s disease

Abstract Amyloid plaques are a hallmark of Alzheimer’s disease (AD) that develop in its earliest stages. Thus, non-invasive detection of these plaques would be invaluable for diagnosis and the development and monitoring of treatments, but this remains a challenge due to their small size. Here, we in...

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Bibliographic Details
Main Authors: Eugene Kim, Davide Di Censo, Mattia Baraldo, Camilla Simmons, Ilaria Rosa, Karen Randall, Clive Ballard, Ben R. Dickie, Steven C. R. Williams, Richard Killick, Diana Cash
Format: Article
Language:English
Published: Nature Portfolio 2021-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-91899-5