Investigation of an 18F-labelled Imidazopyridotriazine for Molecular Imaging of Cyclic Nucleotide Phosphodiesterase 2A

Investigation of an 18F-labelled Imidazopyridotriazine for Molecular Imaging of Cyclic Nucleotide Phosphodiesterase 2A

Specific radioligands for in vivo visualization and quantification of cyclic nucleotide phosphodiesterase 2A (PDE2A) by positron emission tomography (PET) are increasingly gaining interest in brain research. Herein we describe the synthesis, the 18F-labelling as well as the biological evaluation of...

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Bibliographic Details
Main Authors: Susann Schröder, Barbara Wenzel, Winnie Deuther-Conrad, Rodrigo Teodoro, Mathias Kranz, Matthias Scheunemann, Ute Egerland, Norbert Höfgen, Detlef Briel, Jörg Steinbach, Peter Brust
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Molecules
Subjects:
Phosphodiesterase 2A (PDE2A)
secondary messengers
PDE2A radioligands
positron emission tomography (PET)
neuroimaging
metabolic stability
micellar liquid chromatography (MLC)
Online Access:http://www.mdpi.com/1420-3049/23/3/556

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http://www.mdpi.com/1420-3049/23/3/556

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