A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells

A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells

Germline mutations in BRCA1 or BRCA2 tumour suppressor genes predispose to different cancers, as does oncogene activation. Here the authors reveal that aberrant transcription of specific genes triggered by activation of the oncogene β-catenin causes replication failure and cell death in the context...

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Bibliographic Details
Main Authors: Rebecca A. Dagg, Gijs Zonderland, Emilia Puig Lombardi, Giacomo G. Rossetti, Florian J. Groelly, Sonia Barroso, Eliana M. C. Tacconi, Benjamin Wright, Helen Lockstone, Andrés Aguilera, Thanos D. Halazonetis, Madalena Tarsounas
Format: Article
Language:English
Published: Nature Portfolio 2021-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25215-0

Internet

https://doi.org/10.1038/s41467-021-25215-0

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