A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells
Germline mutations in BRCA1 or BRCA2 tumour suppressor genes predispose to different cancers, as does oncogene activation. Here the authors reveal that aberrant transcription of specific genes triggered by activation of the oncogene β-catenin causes replication failure and cell death in the context...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-25215-0 |
| _version_ | 1831584857090686976 |
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| author | Rebecca A. Dagg Gijs Zonderland Emilia Puig Lombardi Giacomo G. Rossetti Florian J. Groelly Sonia Barroso Eliana M. C. Tacconi Benjamin Wright Helen Lockstone Andrés Aguilera Thanos D. Halazonetis Madalena Tarsounas |
| author_facet | Rebecca A. Dagg Gijs Zonderland Emilia Puig Lombardi Giacomo G. Rossetti Florian J. Groelly Sonia Barroso Eliana M. C. Tacconi Benjamin Wright Helen Lockstone Andrés Aguilera Thanos D. Halazonetis Madalena Tarsounas |
| author_sort | Rebecca A. Dagg |
| collection | DOAJ |
| description | Germline mutations in BRCA1 or BRCA2 tumour suppressor genes predispose to different cancers, as does oncogene activation. Here the authors reveal that aberrant transcription of specific genes triggered by activation of the oncogene β-catenin causes replication failure and cell death in the context of BRCA1/2 deficiency. |
| first_indexed | 2024-12-17T21:07:54Z |
| format | Article |
| id | doaj.art-df2c21948aa4474d8a16c5c108679eec |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T21:07:54Z |
| publishDate | 2021-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-df2c21948aa4474d8a16c5c108679eec2022-12-21T21:32:33ZengNature PortfolioNature Communications2041-17232021-08-0112111710.1038/s41467-021-25215-0A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cellsRebecca A. Dagg0Gijs Zonderland1Emilia Puig Lombardi2Giacomo G. Rossetti3Florian J. Groelly4Sonia Barroso5Eliana M. C. Tacconi6Benjamin Wright7Helen Lockstone8Andrés Aguilera9Thanos D. Halazonetis10Madalena Tarsounas11Genome Stability and Tumourigenesis Group, MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of OxfordGenome Stability and Tumourigenesis Group, MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of OxfordGenome Stability and Tumourigenesis Group, MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of OxfordDepartment of Molecular Biology, University of GenevaGenome Stability and Tumourigenesis Group, MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of OxfordCentro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas-Universidad Pablo de OlavideGenome Stability and Tumourigenesis Group, MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of OxfordBioinformatics and Statistical Genetics Core, Wellcome Trust Centre for Human Genetics, University of OxfordBioinformatics and Statistical Genetics Core, Wellcome Trust Centre for Human Genetics, University of OxfordCentro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas-Universidad Pablo de OlavideDepartment of Molecular Biology, University of GenevaGenome Stability and Tumourigenesis Group, MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of OxfordGermline mutations in BRCA1 or BRCA2 tumour suppressor genes predispose to different cancers, as does oncogene activation. Here the authors reveal that aberrant transcription of specific genes triggered by activation of the oncogene β-catenin causes replication failure and cell death in the context of BRCA1/2 deficiency.https://doi.org/10.1038/s41467-021-25215-0 |
| spellingShingle | Rebecca A. Dagg Gijs Zonderland Emilia Puig Lombardi Giacomo G. Rossetti Florian J. Groelly Sonia Barroso Eliana M. C. Tacconi Benjamin Wright Helen Lockstone Andrés Aguilera Thanos D. Halazonetis Madalena Tarsounas A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells Nature Communications |
| title | A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells |
| title_full | A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells |
| title_fullStr | A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells |
| title_full_unstemmed | A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells |
| title_short | A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells |
| title_sort | transcription based mechanism for oncogenic β catenin induced lethality in brca1 2 deficient cells |
| url | https://doi.org/10.1038/s41467-021-25215-0 |
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