Genetic polymorphisms influencing deferasirox pharmacokinetics, efficacy, and adverse drug reactions: a systematic review and meta-analysis

Genetic polymorphisms influencing deferasirox pharmacokinetics, efficacy, and adverse drug reactions: a systematic review and meta-analysis

Objective: Deferasirox is an iron-chelating agent prescribed to patients with iron overload. Due to the interindividual variability of deferasirox responses reported in various populations, this study aims to determine the genetic polymorphisms that influence drug responses.Methods: A systematic sea...

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Bibliographic Details
Main Authors: Kittika Yampayon, Puree Anantachoti, Bunchai Chongmelaxme, Varalee Yodsurang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Pharmacology
Subjects:
deferasirox (DFX)
pharmacogenomics (PGx)
pharmacokinetics
pharmacodynamics
systematic reviews
meta-analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1069854/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1069854/full

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