Transcriptome analysis of synaptoneurosomes identifies neuroplasticity genes overexpressed in incipient Alzheimer's disease.

Transcriptome analysis of synaptoneurosomes identifies neuroplasticity genes overexpressed in incipient Alzheimer's disease.

In Alzheimer's disease (AD), early deficits in learning and memory are a consequence of synaptic modification induced by toxic beta-amyloid oligomers (oAbeta). To identify immediate molecular targets downstream of oAbeta binding, we prepared synaptoneurosomes from prefrontal cortex of control a...

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Bibliographic Details
Main Authors: Celia Williams, Ruty Mehrian Shai, Yongchun Wu, Ya-Hsuan Hsu, Traci Sitzer, Bryan Spann, Carol McCleary, Yi Mo, Carol A Miller
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2654156?pdf=render

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http://europepmc.org/articles/PMC2654156?pdf=render

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