Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function

Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function

Loss-of-function mutations in the DJ-1 gene account for an autosomal recessive form of Parkinson's disease (PD). To investigate the physiological functions of DJ-1 in vivo, we generated DJ-1 knockout (DJ-1−/−) mice. Younger (<1 year) DJ-1−/− mice were hypoactive and had mild gait abnormaliti...

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Bibliographic Details
Main Authors: Jayanth S. Chandran, Xian Lin, Agustin Zapata, Ahmet Höke, Mika Shimoji, Shonagh O'Leary Moore, Matthew P. Galloway, Fiona M. Laird, Philip C. Wong, Donald L. Price, Kathleen R. Bailey, Jacqueline N. Crawley, Toni Shippenberg, Huaibin Cai
Format: Article
Language:English
Published: Elsevier 2008-03-01
Series:Neurobiology of Disease
Subjects:
DJ-1
Knockout mouse
Parkinson's disease
Dopamine
Striatum
Spinal cord
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996107002604

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http://www.sciencedirect.com/science/article/pii/S0969996107002604

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