Design, Synthesis, Kinetic Analysis and Pharmacophore-Directed Discovery of 3-Ethylaniline Hybrid Imino-Thiazolidinone as Potential Inhibitor of Carbonic Anhydrase II: An Emerging Biological Target for Treatment of Cancer

Design, Synthesis, Kinetic Analysis and Pharmacophore-Directed Discovery of 3-Ethylaniline Hybrid Imino-Thiazolidinone as Potential Inhibitor of Carbonic Anhydrase II: An Emerging Biological Target for Treatment of Cancer

Carbonic anhydrases (CA), having Zn<sup>2+</sup> metal atoms, are responsible for the catalysis of CO<sub>2</sub> and water to bicarbonate and protons. Any abnormality in the functioning of these enzymes may lead to morbidities such as glaucoma and different types of cancers...

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Bibliographic Details
Main Authors: Atteeque Ahmed, Mubashir Aziz, Syeda Abida Ejaz, Pervaiz Ali Channar, Aamer Saeed, Seema Zargar, Tanveer A. Wani, Asad Hamad, Qamar Abbas, Hussain Raza, Song Ja Kim
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Biomolecules
Subjects:
3-ethylaniline hybrid imino-thiazolidinones
carbonic anhydrase II
DFT studies
molecular docking
molecular dynamic simulation
drug likeness scores
Online Access:https://www.mdpi.com/2218-273X/12/11/1696

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https://www.mdpi.com/2218-273X/12/11/1696

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