A limited sampling strategy for estimating busulfan exposure in pediatric hematopoietic stem cell transplantation

A limited sampling strategy for estimating busulfan exposure in pediatric hematopoietic stem cell transplantation

BackgroundBusulfan (Bu) is the foundation of conditioning regimens for pediatric hematopoietic stem cell transplantation (HSCT). Evidence indicates that the efficacy and side effects of Bu are intimately tied to the area under its concentration-time curve (AUC). Given its cytotoxic nature and a smal...

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Bibliographic Details
Main Authors: Chenhong Jia, Yabin Qin, Yu Han, Weijing Ding, Yuntao Pei, Yile Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Pharmacology
Subjects:
busulfan
pediatric hematopoietic stem cell transplantation
limited sampling strategy
therapeutic drug monitoring
area under the concentration-time curve
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1540139/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2025.1540139/full

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