The Inactivation of JAK2/STAT3 Signaling and Desensitization of M1 mAChR in Minimal Hepatic Encephalopathy (MHE) and the Protection of Naringin Against MHE

The Inactivation of JAK2/STAT3 Signaling and Desensitization of M1 mAChR in Minimal Hepatic Encephalopathy (MHE) and the Protection of Naringin Against MHE

Background: We previously reported that elevation of intracranial dopamine (DA) levels from cirrhotic livers is implicated in the pathogenesis of minimal hepatic encephalopathy (MHE). Intracellular events in neurons, which lead to memory loss in MHE by elevated DA, however, remain elusive. Methods:...

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Bibliographic Details
Main Authors: Saidan Ding, Jiangnan Hu, Jianjing Yang, Leping Liu, Weilong Huang, Xialong Gu, Yiru Ye, Lijie Huang, Yong Liang, Bicheng Chen, Qichuan Zhuge
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Minimal hepatic encephalopathy (MHE)
Dopamine
Memory impairment
JAK2/STAT3 axis
M1-type muscarinic acetylcholine receptor (M1 mAChR)
Online Access:http://www.karger.com/Article/FullText/366391

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http://www.karger.com/Article/FullText/366391

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