Single-Cell Analysis of Antigen-Specific CD8+ T-Cell Transcripts Reveals Profiles Specific to mRNA or Adjuvanted Protein Vaccines

Single-Cell Analysis of Antigen-Specific CD8+ T-Cell Transcripts Reveals Profiles Specific to mRNA or Adjuvanted Protein Vaccines

CD8+ T cells play a key role in mediating protective immunity after immune challenges such as infection or vaccination. Several subsets of differentiated CD8+ T cells have been identified, however, a deeper understanding of the molecular mechanism that underlies T-cell differentiation is lacking. Co...

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Bibliographic Details
Main Authors: Trine Sundebo Meldgaard, Fabiola Blengio, Denise Maffione, Chiara Sammicheli, Simona Tavarini, Sandra Nuti, Roland Kratzer, Duccio Medini, Emilio Siena, Sylvie Bertholet
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
CD8+ T cells
single-cell
heterogeneity
gene expression
self-amplifying mRNA
vaccines
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.757151/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.757151/full

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