Transcriptional control of a collagen deposition and adhesion process that promotes lung adenocarcinoma growth and metastasis

A fibrotic stroma accumulates in advanced cancers, and invasive cancer cells migrate along collagen fibers that facilitate dissemination from the primary tumor. However, the ways in which tumor cells govern these processes remain unclear. Here, we report that the epithelial-mesenchymal transition–ac...

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Bibliographic Details
Main Authors: Xiaochao Tan, Priyam Banerjee, Xin Liu, Jiang Yu, Sieun Lee, Young-Ho Ahn, Chad J. Creighton, Jonathan M. Kurie
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-01-01
Series:JCI Insight
Subjects:
Online Access:https://doi.org/10.1172/jci.insight.153948