LC–MS/MS based-comparative study of (S)-nicotine metabolism by microorganisms, mushroom and plant cultures: Parallels to its mammalian metabolic fate

LC–MS/MS based-comparative study of (S)-nicotine metabolism by microorganisms, mushroom and plant cultures: Parallels to its mammalian metabolic fate

The metabolic fate of nicotine using the cell cultures of microorganisms, mushroom and plants was explored using LC–MS/MS analysis. The study demonstrated parallels to phase I mammalian metabolism of nicotine and reported that nicotine was biotransformed into its N-oxide by Streptomyces fradiae cult...

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Bibliographic Details
Main Authors: Amira R. Khattab, Abdel-Rahim S. Ibrahim, Souzan M. Ibrahim, Kamillia A. Abou El-Seoud, Wafaa E. Soliman, Fathy K. El-Fiky
Format: Article
Language:English
Published: Faculty of Pharmacy, Cairo University 2015-12-01
Series:Bulletin of Faculty of Pharmacy Cairo University
Subjects:
Microbial biotransformation
Mammalian metabolism
Nicotine
Plant cell culture
Liquid chromatography–mass spectrometry (LC–MS/MS)
Online Access:http://www.sciencedirect.com/science/article/pii/S1110093115000241

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http://www.sciencedirect.com/science/article/pii/S1110093115000241

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