Loss of the Intellectual Disability and Autism Gene Cc2d1a and Its Homolog Cc2d1b Differentially Affect Spatial Memory, Anxiety, and Hyperactivity

Loss of the Intellectual Disability and Autism Gene Cc2d1a and Its Homolog Cc2d1b Differentially Affect Spatial Memory, Anxiety, and Hyperactivity

Hundreds of genes are mutated in non-syndromic intellectual disability (ID) and autism spectrum disorder (ASD), with each gene often involved in only a handful of cases. Such heterogeneity can be daunting, but rare recessive loss of function (LOF) mutations can be a good starting point to provide in...

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Bibliographic Details
Main Authors: Marta Zamarbide, Adam W. Oaks, Heather L. Pond, Julia S. Adelman, M. Chiara Manzini
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Genetics
Subjects:
intellectual disability
learning
social function
anxiety
hyperactivity
rare diseases
Online Access:http://journal.frontiersin.org/article/10.3389/fgene.2018.00065/full

Internet

http://journal.frontiersin.org/article/10.3389/fgene.2018.00065/full

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