Restoration of BDNF, DARPP32, and D2R Expression Following Intravenous Infusion of Human Immature Dental Pulp Stem Cells in Huntington’s Disease 3-NP Rat Model

Huntington’s disease (HD) is a neurodegenerative inherited genetic disorder, which leads to the onset of motor, neuropsychiatric and cognitive disturbances. HD is characterized by the loss of gamma-aminobutyric acid (GABA)ergic medium spiny neurons (MSNs). To date, there is no treatment for HD. Mese...

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Main Authors: Cristiane Valverde Wenceslau, Dener Madeiro de Souza, Nicole Caroline Mambelli-Lisboa, Leandro Hideki Ynoue, Rodrigo Pinheiro Araldi, Joyce Macedo da Silva, Eduardo Pagani, Monica Santoro Haddad, Irina Kerkis
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Cells
Subjects:
Online Access:https://www.mdpi.com/2073-4409/11/10/1664