Effect of the renin-angiotensin system on the exacerbation of adrenal glucocorticoid steroidogenesis in diabetic mice: Role of angiotensin-II type 2 receptor

Effect of the renin-angiotensin system on the exacerbation of adrenal glucocorticoid steroidogenesis in diabetic mice: Role of angiotensin-II type 2 receptor

Prior investigation shows an increase in the activity of both hypothalamus-pituitary-adrenal (HPA) axis and the renin-angiotensin system (RAS) in diabetic patients. Moreover, activation of angiotensin-II type 1 receptor (AT1) has been associated with adrenal steroidogenesis. This study investigates...

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Bibliographic Details
Main Authors: Amanda da Silva Chaves, Nathalia Santos Magalhães, Daniella Bianchi Reis Insuela, Patrícia Machado Rodrigues E. Silva, Marco Aurélio Martins, Vinicius Frias Carvalho
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Endocrinology
Subjects:
angiotensin II receptors
diabetes
glucocorticoids
renin-angiotensin system
steroidogenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.1040040/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2022.1040040/full

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