Reprogramming Mycobacterium tuberculosis CRISPR System for Gene Editing and Genome-wide RNA Interference Screening

Reprogramming Mycobacterium tuberculosis CRISPR System for Gene Editing and Genome-wide RNA Interference Screening

Mycobacterium tuberculosis is the causative agent of tuberculosis (TB), which is still the leading cause of mortality from a single infectious disease worldwide. The development of novel anti-TB drugs and vaccines is severely hampered by the complicated and time-consuming genetic manipulation techni...

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Bibliographic Details
Main Authors: Khaista Rahman, Muhammad Jamal, Xi Chen, Wei Zhou, Bin Yang, Yanyan Zou, Weize Xu, Yingying Lei, Chengchao Wu, Xiaojian Cao, Rohit Tyagi, Muhammad Ahsan Naeem, Da Lin, Zeshan Habib, Nan Peng, Zhen F. Fu, Gang Cao
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Genomics, Proteomics & Bioinformatics
Subjects:
Mycobacterium tuberculosis
Type III-A CRISPR system
Gene editing
Gene interference
Genome-wide RNAi screening
Online Access:http://www.sciencedirect.com/science/article/pii/S1672022921002497

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http://www.sciencedirect.com/science/article/pii/S1672022921002497

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