G-Quadruplex Aptamer-Ligand Characterization

G-Quadruplex Aptamer-Ligand Characterization

In this work we explore the structure of a G-rich DNA aptamer termed AT11-L2 (TGGTGGTGGTTGTTGTTGGTGGTGGTGGT; derivative of AT11) by evaluating the formation and stability of G-quadruplex (G4) conformation under different experimental conditions such as KCl concentration, temperature, and upon bindin...

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Bibliographic Details
Main Authors: David Moreira, Daniela Leitão, Jéssica Lopes-Nunes, Tiago Santos, Joana Figueiredo, André Miranda, Daniela Alexandre, Cândida Tomaz, Jean-Louis Mergny, Carla Cruz
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Molecules
Subjects:
G-quadruplex aptamer
ligands
aptamer–ligand interactions
biophysical techniques
Online Access:https://www.mdpi.com/1420-3049/27/20/6781

Internet

https://www.mdpi.com/1420-3049/27/20/6781

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