Dihydroartemisinin-piperaquine or sulphadoxine-pyrimethamine for the chemoprevention of malaria in children with sickle cell anaemia in eastern and southern Africa (CHEMCHA): a protocol for a multi-centre, two-arm, double-blind, randomised, placebo-controlled superiority trial

Dihydroartemisinin-piperaquine or sulphadoxine-pyrimethamine for the chemoprevention of malaria in children with sickle cell anaemia in eastern and southern Africa (CHEMCHA): a protocol for a multi-centre, two-arm, double-blind, randomised, placebo-controlled superiority trial

Abstract Background An estimated 300,000 babies are born with sickle cell anaemia (SCA) annually. Affected children have chronic ill health and suffer premature death. Febrile illnesses such as malaria commonly precipitate acute crises in children with SCA. Thus, chemoprophylaxis for malaria is an i...

Full description

Bibliographic Details
Main Authors: Thandile Nkosi-Gondwe, Bjarne Robberstad, Robert Opoka, Dennis Kalibbala, Joseph Rujumba, Lufina Tsirizani Galileya, Pamela Akun, Winnie Nambatya, John Ssenkusu, Feiko TerKuile, Kamija Phiri, Richard Idro
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Trials
Subjects:
Malaria
Sickle cell anaemia
Chemoprevention
Mortality
Dihydroartemisinin-piperaquine
Sulphadoxine-pyrimethamine
Online Access:https://doi.org/10.1186/s13063-023-07274-4

Internet

https://doi.org/10.1186/s13063-023-07274-4

Similar Items