Oxidative Damage in Sporadic Colorectal Cancer: Molecular Mapping of Base Excision Repair Glycosylases MUTYH and hOGG1 in Colorectal Cancer Patients

Oxidative Damage in Sporadic Colorectal Cancer: Molecular Mapping of Base Excision Repair Glycosylases MUTYH and hOGG1 in Colorectal Cancer Patients

Oxidative stress, oxidative DNA damage and resulting mutations play a role in colorectal carcinogenesis. Impaired equilibrium between DNA damage formation, antioxidant status, and DNA repair capacity is responsible for the accumulation of genetic mutations and genomic instability. The lesion-specifi...

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Bibliographic Details
Main Authors: Miriam J. Kavec, Marketa Urbanova, Pavol Makovicky, Alena Opattová, Kristyna Tomasova, Michal Kroupa, Klara Kostovcikova, Anna Siskova, Nazila Navvabi, Michaela Schneiderova, Veronika Vymetalkova, Ludmila Vodickova, Pavel Vodicka
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:International Journal of Molecular Sciences
Subjects:
Oxidative DNA damage
DNA repair
BER glycosylases
colorectal cancer
Online Access:https://www.mdpi.com/1422-0067/23/10/5704

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https://www.mdpi.com/1422-0067/23/10/5704

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