Tetrahydro-2-furanyl-2,4(1H,3H)-pyrimidinedione derivatives as novel antibacterial compounds against Mycobacterium

Tetrahydro-2-furanyl-2,4(1H,3H)-pyrimidinedione derivatives as novel antibacterial compounds against Mycobacterium

Objective/Background: Mycobacterium tuberculosis thymidine monophosphate kinase (mtTMPK) is a potential enzymatic target for the treatment of tuberculosis (TB). Materials and Methods: In this study, we performed pharmacophore-based in silico screening, targeting mtTMPK with a compound library of 461...

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Bibliographic Details
Main Authors: Yuji Koseki, Hironori Kanetaka, Joji Tsunosaki, Héléne Munier-Lehmann, Shunsuke Aoki
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2017-01-01
Series:International Journal of Mycobacteriology
Subjects:
In silico drug screening
Mycobacterium
pharmacophore model
thymidine monophosphate kinase
Online Access:http://www.ijmyco.org/article.asp?issn=2212-5531;year=2017;volume=6;issue=1;spage=61;epage=69;aulast=Koseki

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http://www.ijmyco.org/article.asp?issn=2212-5531;year=2017;volume=6;issue=1;spage=61;epage=69;aulast=Koseki

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