New functions of Ctf18-RFC in preserving genome stability outside its role in sister chromatid cohesion.

New functions of Ctf18-RFC in preserving genome stability outside its role in sister chromatid cohesion.

Expansion of DNA trinucleotide repeats causes at least 15 hereditary neurological diseases, and these repeats also undergo contraction and fragility. Current models to explain this genetic instability invoke erroneous DNA repair or aberrant replication. Here we show that CAG/CTG tracts are stabilize...

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Bibliographic Details
Main Authors: Lionel Gellon, David F Razidlo, Olive Gleeson, Lauren Verra, Danae Schulz, Robert S Lahue, Catherine H Freudenreich
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-02-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3037408?pdf=render

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http://europepmc.org/articles/PMC3037408?pdf=render

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