A sophisticated mechanism governs Pol ζ activity in response to replication stress

A sophisticated mechanism governs Pol ζ activity in response to replication stress

Abstract DNA polymerase ζ (Pol ζ) plays an essential role in replicating damaged DNA templates but contributes to mutagenesis due to its low fidelity. Therefore, ensuring tight control of Pol ζ’s activity is critical for continuous and accurate DNA replication, yet the specific mechanisms remain unc...

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Bibliografiske detaljer
Main Authors: Chun Li, Shuchen Fan, Pan Li, Yuzhen Bai, Ye Wang, Yueyun Cui, Mengdi Li, Ruru Wang, Yuan Shao, Yingying Wang, Shuo Zheng, Rong Wang, Lijun Gao, Miaomiao Li, Yuanyuan Zheng, Fengting Wang, Sihang Gao, Shiguo Feng, Jianing Wang, Xinqi Qu, Xialu Li
Format: Article
Sprog:English
Udgivet: Nature Portfolio 2024-08-01
Serier:Nature Communications
Online adgang:https://doi.org/10.1038/s41467-024-52112-z

Internet

https://doi.org/10.1038/s41467-024-52112-z

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