Sustained inhibition of NPY/AgRP neuronal activity by FGF1

Sustained inhibition of NPY/AgRP neuronal activity by FGF1

In rodent models of type 2 diabetes (T2D), central administration of FGF1 normalizes elevated blood glucose levels in a manner that is sustained for weeks or months. Increased activity of NPY/AgRP neurons in the hypothalamic arcuate nucleus (ARC) is implicated in the pathogenesis of hyperglycemia in...

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Bibliographic Details
Main Authors: Eunsang Hwang, Jarrad M. Scarlett, Arian F. Baquero, Camdin M. Bennett, Yanbin Dong, Dominic Chau, Jenny M. Brown, Aaron J. Mercer, Thomas H. Meek, Kevin L. Grove, Bao Anh N. Phan, Gregory J. Morton, Kevin W. Williams, Michael W. Schwartz
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-09-01
Series:JCI Insight
Subjects:
Endocrinology
Neuroscience
Online Access:https://doi.org/10.1172/jci.insight.160891

Internet

https://doi.org/10.1172/jci.insight.160891

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