Disruption of the Snf1 Gene Enhances Cell Growth and Reduces the Metabolic Burden in Cellulase-Expressing and Lipid-Accumulating Yarrowia lipolytica

Disruption of the Snf1 Gene Enhances Cell Growth and Reduces the Metabolic Burden in Cellulase-Expressing and Lipid-Accumulating Yarrowia lipolytica

Yarrowia lipolytica is known to be capable of metabolizing glucose and accumulating lipids intracellularly; however, it lacks the cellulolytic enzymes needed to break down cellulosic biomass directly. To develop Y. lipolytica as a consolidated bioprocessing (CBP) microorganism, we previously express...

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Bibliographic Details
Main Authors: Hui Wei, Wei Wang, Eric P. Knoshaug, Xiaowen Chen, Stefanie Van Wychen, Yannick J. Bomble, Michael E. Himmel, Min Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Microbiology
Subjects:
Yarrowia lipolytica
cellobiohydrolase I
endoglucanase II
lipid metabolism
ATP citrate lyase
diacylglycerol acyltransferase
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.757741/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2021.757741/full

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