Mirror proteases of Ac-Trypsin and Ac-LysargiNase precisely improve novel event identifications in Mycolicibacterium smegmatis MC2 155 by proteogenomic analysis

Accurate identification of novel peptides remains challenging because of the lack of evaluation criteria in large-scale proteogenomic studies. Mirror proteases of trypsin and lysargiNase can generate complementary b/y ion series, providing the opportunity to efficiently assess authentic novel peptid...

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Bibliographic Details
Main Authors: Songhao Jiang, Jiahui Shi, Yanchang Li, Zhenpeng Zhang, Lei Chang, Guibin Wang, Wenhui Wu, Liyan Yu, Erhei Dai, Lixia Zhang, Zhitang Lyu, Ping Xu, Yao Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Microbiology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.1015140/full