Fragment-Based Lead Discovery Strategies in Antimicrobial Drug Discovery

Fragment-Based Lead Discovery Strategies in Antimicrobial Drug Discovery

Fragment-based lead discovery (FBLD) is a powerful application for developing ligands as modulators of disease targets. This approach strategy involves identification of interactions between low-molecular weight compounds (100–300 Da) and their putative targets, often with low affinity (K<sub>...

Full description

Bibliographic Details
Main Authors: Monika I. Konaklieva, Balbina J. Plotkin
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Antibiotics
Subjects:
FBLD
antimicrobial
multidrug resistance
inhibitors of pathogenic bacterial enzymes
phenotypic screens
STD NMR
Online Access:https://www.mdpi.com/2079-6382/12/2/315

Internet

https://www.mdpi.com/2079-6382/12/2/315

Similar Items