DNA methylation-activated full-length EMX1 facilitates metastasis through EMX1-EGFR-ERK axis in hepatocellular carcinoma

Abstract Altered DNA methylation is a crucial epigenetic event in hepatocellular carcinoma (HCC) development and progression. Through methylation-transcriptomic analysis, we identified a set of sixty potential DNA methylation-based epidriver genes. In this set of genes, we focused on the hypermethyl...

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Bibliographic Details
Main Authors: Dong-sheng Wen, Li-chang Huang, Xiao-yun Bu, Min-ke He, Zhi-cheng Lai, Ze-feng Du, Ye-xing Huang, Anna Kan, Ming Shi
Format: Article
Language:English
Published: Nature Publishing Group 2023-11-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-06293-y