Thioesters provide a plausible prebiotic path to proto-peptides

One of the early processes enabling the origins of life is thought to be the condensation of building blocks into oligomers and polymers. In this article, the authors report the synthesis of thiodepsipeptides and HS-peptides under mild temperatures and various pH, suggesting they could have formed o...

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Bibliographic Details
Main Authors: Moran Frenkel-Pinter, Marcos Bouza, Facundo M. Fernández, Luke J. Leman, Loren Dean Williams, Nicholas V. Hud, Aikomari Guzman-Martinez
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-30191-0