Exogenous expression of ATP8, a mitochondrial encoded protein, from the nucleus in vivo

Exogenous expression of ATP8, a mitochondrial encoded protein, from the nucleus in vivo

Replicative errors, inefficient repair, and proximity to sites of reactive oxygen species production make mitochondrial DNA (mtDNA) susceptible to damage with time. We explore in vivo allotopic expression (re-engineering mitochondrial genes and expressing them from the nucleus) as an approach to res...

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Bibliographic Details
Main Authors: David V. Begelman, Bhavna Dixit, Carly Truong, Christina D. King, Mark A. Watson, Birgit Schilling, Martin D. Brand, Amutha Boominathan
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
allotopic expression
mitochondrial DNA mutation
mtDNA
ATP8 gene
transgenic mouse
in vivo gene therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050124001888

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http://www.sciencedirect.com/science/article/pii/S2329050124001888

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