Bi-Functional Alginate Oligosaccharide–Polymyxin Conjugates for Improved Treatment of Multidrug-Resistant Gram-Negative Bacterial Infections

Bi-Functional Alginate Oligosaccharide–Polymyxin Conjugates for Improved Treatment of Multidrug-Resistant Gram-Negative Bacterial Infections

The recent emergence of resistance to colistin, an antibiotic of last resort with dose-limiting toxicity, has highlighted the need for alternative approaches to combat infection. This study aimed to generate and characterise alginate oligosaccharide (“OligoG”)–polymyxin (polymyxin B and E (colistin)...

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Bibliographic Details
Main Authors: Joana Stokniene, Lydia C. Powell, Olav A. Aarstad, Finn L. Aachmann, Philip D. Rye, Katja E. Hill, David W. Thomas, Elaine L. Ferguson
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Pharmaceutics
Subjects:
gram-negative bacteria
multidrug resistance
polymer therapeutics
colistin
polymyxin B
Online Access:https://www.mdpi.com/1999-4923/12/11/1080

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https://www.mdpi.com/1999-4923/12/11/1080

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