The role of cells and signal pathways in subchondral bone in osteoarthritis
Osteoarthritis (OA) is mainly caused by ageing, strain, trauma, and congenital joint abnormalities, resulting in articular cartilage degeneration. During the pathogenesis of OA, the changes in subchondral bone (SB) are not only secondary manifestations of OA, but also an active part of the disease,...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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The British Editorial Society of Bone & Joint Surgery
2023-09-01
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| Series: | Bone & Joint Research |
| Subjects: | |
| Online Access: | https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.129.BJR-2023-0081.R1 |
| _version_ | 1797671839425626112 |
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| author | Pan Luo Qi-ling Yuan Mingyi Yang Xianjie Wan Peng Xu |
| author_facet | Pan Luo Qi-ling Yuan Mingyi Yang Xianjie Wan Peng Xu |
| author_sort | Pan Luo |
| collection | DOAJ |
| description | Osteoarthritis (OA) is mainly caused by ageing, strain, trauma, and congenital joint abnormalities, resulting in articular cartilage degeneration. During the pathogenesis of OA, the changes in subchondral bone (SB) are not only secondary manifestations of OA, but also an active part of the disease, and are closely associated with the severity of OA. In different stages of OA, there were microstructural changes in SB. Osteocytes, osteoblasts, and osteoclasts in SB are important in the pathogenesis of OA. The signal transduction mechanism in SB is necessary to maintain the balance of a stable phenotype, extracellular matrix (ECM) synthesis, and bone remodelling between articular cartilage and SB. An imbalance in signal transduction can lead to reduced cartilage quality and SB thickening, which leads to the progression of OA. By understanding changes in SB in OA, researchers are exploring drugs that can regulate these changes, which will help to provide new ideas for the treatment of OA. Cite this article: Bone Joint Res 2023;12(9):536–545. |
| first_indexed | 2024-03-11T21:21:20Z |
| format | Article |
| id | doaj.art-df789a06dcb14b238a9d1a0014de364d |
| institution | Directory Open Access Journal |
| issn | 2046-3758 |
| language | English |
| last_indexed | 2024-03-11T21:21:20Z |
| publishDate | 2023-09-01 |
| publisher | The British Editorial Society of Bone & Joint Surgery |
| record_format | Article |
| series | Bone & Joint Research |
| spelling | doaj.art-df789a06dcb14b238a9d1a0014de364d2023-09-28T06:55:49ZengThe British Editorial Society of Bone & Joint SurgeryBone & Joint Research2046-37582023-09-0112953654510.1302/2046-3758.129.BJR-2023-0081.R1The role of cells and signal pathways in subchondral bone in osteoarthritisPan Luo0https://orcid.org/0000-0003-0192-5112Qi-ling Yuan1https://orcid.org/0000-0002-4822-2513Mingyi Yang2https://orcid.org/0000-0001-8640-9795Xianjie Wan3https://orcid.org/0000-0002-2749-3621Peng Xu4https://orcid.org/0000-0003-2487-9163Department of Joint Surgery, HongHui Hospital, Xi’an Jiaotong University, Xi'an, ChinaDepartment of Joint Surgery, HongHui Hospital, Xi’an Jiaotong University, Xi'an, ChinaDepartment of Joint Surgery, HongHui Hospital, Xi’an Jiaotong University, Xi'an, ChinaDepartment of Joint Surgery, HongHui Hospital, Xi’an Jiaotong University, Xi'an, ChinaDepartment of Joint Surgery, HongHui Hospital, Xi’an Jiaotong University, Xi'an, ChinaOsteoarthritis (OA) is mainly caused by ageing, strain, trauma, and congenital joint abnormalities, resulting in articular cartilage degeneration. During the pathogenesis of OA, the changes in subchondral bone (SB) are not only secondary manifestations of OA, but also an active part of the disease, and are closely associated with the severity of OA. In different stages of OA, there were microstructural changes in SB. Osteocytes, osteoblasts, and osteoclasts in SB are important in the pathogenesis of OA. The signal transduction mechanism in SB is necessary to maintain the balance of a stable phenotype, extracellular matrix (ECM) synthesis, and bone remodelling between articular cartilage and SB. An imbalance in signal transduction can lead to reduced cartilage quality and SB thickening, which leads to the progression of OA. By understanding changes in SB in OA, researchers are exploring drugs that can regulate these changes, which will help to provide new ideas for the treatment of OA. Cite this article: Bone Joint Res 2023;12(9):536–545.https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.129.BJR-2023-0081.R1subchondral boneosteoarthritisbone remodellingosteoarthritis (oa)osteoblastic cellsbone remodellingosteoclastscartilageosteocytesarticular cartilagepathogenesisstrain |
| spellingShingle | Pan Luo Qi-ling Yuan Mingyi Yang Xianjie Wan Peng Xu The role of cells and signal pathways in subchondral bone in osteoarthritis Bone & Joint Research subchondral bone osteoarthritis bone remodelling osteoarthritis (oa) osteoblastic cells bone remodelling osteoclasts cartilage osteocytes articular cartilage pathogenesis strain |
| title | The role of cells and signal pathways in subchondral bone in osteoarthritis |
| title_full | The role of cells and signal pathways in subchondral bone in osteoarthritis |
| title_fullStr | The role of cells and signal pathways in subchondral bone in osteoarthritis |
| title_full_unstemmed | The role of cells and signal pathways in subchondral bone in osteoarthritis |
| title_short | The role of cells and signal pathways in subchondral bone in osteoarthritis |
| title_sort | role of cells and signal pathways in subchondral bone in osteoarthritis |
| topic | subchondral bone osteoarthritis bone remodelling osteoarthritis (oa) osteoblastic cells bone remodelling osteoclasts cartilage osteocytes articular cartilage pathogenesis strain |
| url | https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.129.BJR-2023-0081.R1 |
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