Synthesis, characterization, and cytotoxicity of doxorubicin-loaded polycaprolactone nanocapsules as controlled anti-hepatocellular carcinoma drug release system

Synthesis, characterization, and cytotoxicity of doxorubicin-loaded polycaprolactone nanocapsules as controlled anti-hepatocellular carcinoma drug release system

Abstract Background Free doxorubicin (Dox) is used as a chemotherapeutic agent against hepatocellular carcinoma (HCC), but it results in cardiotoxicty as a major side effect. Hence, a controlled Dox drug delivery system is extremely demanded. Methods Dox was loaded into the non-toxic biodegradable p...

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Bibliographic Details
Main Authors: Abdelgawad Fahmi, Mariam Abdur-Rahman, Omnia Mahareek, Mohamed A. shemis
Format: Article
Language:English
Published: BMC 2022-11-01
Series:BMC Chemistry
Subjects:
Doxorubicin
Polycaprolactone
Hepatocellular carcinoma
Cardiotoxicity
Nanocapsules
Online Access:https://doi.org/10.1186/s13065-022-00888-w

Internet

https://doi.org/10.1186/s13065-022-00888-w

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