Development of Allogeneic Stem Cell-Based Platform for Delivery and Potentiation of Oncolytic Virotherapy

Development of Allogeneic Stem Cell-Based Platform for Delivery and Potentiation of Oncolytic Virotherapy

We describe the repurposing and optimization of the TK-positive (thymidine kinase) vaccinia virus strain ACAM1000/ACAM2000™ as an oncolytic virus. This virus strain has been widely used as a smallpox vaccine and was also used safely in our recent clinical trial in patients with advanced solid tumors...

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Bibliographic Details
Main Authors: Duong Hoang Nguyen, Thomas Herrmann, Barbara Härtl, Dobrin Draganov, Ivelina Minev, Forrest Neuharth, Alberto Gomez, Ashley Alamillo, Laura Edith Schneider, Daniela Kleinholz, Boris Minev, Antonio F. Santidrian
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cancers
Subjects:
SNV1
Supernova
CAL1
vaccinia virus
oncolytic virus
cell-based platform
Online Access:https://www.mdpi.com/2072-6694/14/24/6136

Internet

https://www.mdpi.com/2072-6694/14/24/6136

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