In vitro evaluation of anti-angiogenesis property of anti-VEGFR2 nanobody-conjugated H40-PEG carrier loaded with methotrexate

In vitro evaluation of anti-angiogenesis property of anti-VEGFR2 nanobody-conjugated H40-PEG carrier loaded with methotrexate

Objective(s): In this study, Boltorn® H40-PEG-MTX-anti-VEGFR2 nanobody was fabricated in which nanobody was selected for blocking the receptor, H40 as a nanocarrier for delivery of methotrexate (MTX) to the tumor cells, and polyethylene glycol (PEG) moieties for improving the blood circulation time...

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Bibliographic Details
Main Authors: Seyed Masih Adyani, Hamid Rashidzadeh, Mahdi Behdani, Seyed Jamal Tabatabaei Rezaei, Ali Ramazani
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2022-12-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
angiogenesis inhibitors
methotrexate
polymer
single-domain antibodies
vascular endothelial - growth factor receptor-2
Online Access:https://ijbms.mums.ac.ir/article_21218_94249941c8ac4e5e7cdc9eeb993f2010.pdf

Internet

https://ijbms.mums.ac.ir/article_21218_94249941c8ac4e5e7cdc9eeb993f2010.pdf

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