Sialylation on O-linked glycans protects von Willebrand factor from macrophage galactose lectin-mediated clearance

Sialylation on O-linked glycans protects von Willebrand factor from macrophage galactose lectin-mediated clearance

Terminal sialylation determines the plasma half-life of von Willebrand factor (VWF). A role for macrophage galactose lectin (MGL) in regulating hyposialylated VWF clearance has recently been proposed. In this study, we showed that MGL influences physiological plasma VWF clearance. MGL inhibition wa...

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Bibliographic Details
Main Authors: Soracha E. Ward, Jamie M. O’Sullivan, Alan B. Moran, Daniel I. R. Spencer, Richard A. Gardner, Jyotika Sharma, Judicael Fazavana, Marco Monopoli, Thomas A.J. McKinnon, Alain Chion, Sandra Haberichter, James S. O’Donnell
Format: Article
Language:English
Published: Ferrata Storti Foundation 2021-03-01
Series:Haematologica
Online Access:https://haematologica.org/article/view/10217

Internet

https://haematologica.org/article/view/10217

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