Anti-c-MET Fab-Grb2-Gab1 Fusion Protein-Mediated Interference of c-MET Signaling Pathway Induces Methuosis in Tumor Cells

Anti-c-MET Fab-Grb2-Gab1 Fusion Protein-Mediated Interference of c-MET Signaling Pathway Induces Methuosis in Tumor Cells

Bio-macromolecules have potential applications in cancer treatment due to their high selectivity and efficiency in hitting therapeutic targets. However, poor cell membrane permeability has limited their broad-spectrum application in cancer treatment. The current study developed highly internalizable...

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Bibliographic Details
Main Authors: Xiaoqian Dou, Qinzhi Xu, Bo Dong, Guili Xu, Niliang Qian, Cuima Yang, Hongjie Li, Liting Chen, Xin Gao, Haifeng Song
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
bio-macromolecules
Fab fusion proteins
dual intervention
signaling pathways
methuosis
intracellular delivery
Online Access:https://www.mdpi.com/1422-0067/23/19/12018

Internet

https://www.mdpi.com/1422-0067/23/19/12018

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