Interrogating the Metabolomic Profile of Amyotrophic Lateral Sclerosis in the Post-Mortem Human Brain by Infrared Matrix-Assisted Laser Desorption Electrospray Ionization (IR-MALDESI) Mass Spectrometry Imaging (MSI)

Amyotrophic lateral sclerosis (ALS) is an idiopathic, fatal neurodegenerative disease characterized by progressive loss of motor function with an average survival time of 2–5 years after diagnosis. Due to the lack of signature biomarkers and heterogenous disease phenotypes, a definitive diagnosis of...

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Bibliographic Details
Main Authors: Alexandria L. Sohn, Lingyan Ping, Jonathan D. Glass, Nicholas T. Seyfried, Emily C. Hector, David C. Muddiman
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Metabolites
Subjects:
Online Access:https://www.mdpi.com/2218-1989/12/11/1096