Improved Metal-Free Approach for the Synthesis of Protected Thiol Containing Thymidine Nucleoside Phosphoramidite and Its Application for the Synthesis of Ligatable Oligonucleotide Conjugates

Improved Metal-Free Approach for the Synthesis of Protected Thiol Containing Thymidine Nucleoside Phosphoramidite and Its Application for the Synthesis of Ligatable Oligonucleotide Conjugates

Oligonucleotide conjugates are versatile scaffolds that can be applied in DNA-based screening platforms and ligand display or as therapeutics. Several different chemical approaches are available for functionalizing oligonucleotides, which are often carried out on the 5′ or 3′ end. Modifying oligonuc...

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Bibliographic Details
Main Authors: Zoltán Kupihár, Györgyi Ferenc, Vencel L. Petrovicz, Viktória R. Fáy, Lajos Kovács, Tamás A. Martinek, Zsófia Hegedüs
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Pharmaceutics
Subjects:
nucleoside synthesis
oligonucleotide conjugates
ligatable oligonucleotides
solid-phase conjugation
thiol-maleimide conjugation
templated ligation
Online Access:https://www.mdpi.com/1999-4923/15/1/248

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https://www.mdpi.com/1999-4923/15/1/248

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